About Tykerb 250mg Tablets : 

Tykerb 250mg is a targeted therapy. It is classified as a signal transduction inhibitor – tyrosine kinase inhibitor, an inhibitor of EGFR and HER2. 

TYKERB 250mg USES : 

Lapatinib 250mg Tablet is used together with another medication (Capecitabine) to treat a certain type of breast cancer (HER2-positive) that has not responded to the standard treatment. It may also be used together with another medication (letrozole) to treat HER2-positive breast cancer in women after menopause. It works by slowing or stopping the growth of cancer cells. 

Lapatinib 250mg Tablets Side Effects : 

Back pain; diarrhea; dry skin; fingernail or toenail changes; headache; indigestion; loss of appetite; mild hair loss or thinning; mouth sores; nausea; nosebleed; redness and tingling of the hands and feet; tiredness; trouble sleeping; vomiting. 

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; dizziness or light-headedness; fast or irregular heartbeat; pale stools; persistent loss of appetite; severe or persistent cough; severe or persistent diarrhea, nausea, vomiting, or stomach cramping or pain; severe pain, redness, or swelling of the hands or feet; severe tiredness or weakness; shortness of breath; unusual bruising or bleeding; unusual itching; yellowing of the eyes or skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

NOVARTIS LAPATINIB PRECAUTIONS : 

• Tell your doctor or dentist that you take Tykerb before you receive any medical or dental care, emergency care, or surgery. 
• Diarrhea is a common side effect of Tykerb. If you get diarrhea, call your doctor right away for instructions on how to treat it. Do not treat diarrhea without first checking with your doctor. 
• A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have symptoms like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes. 
• Lab tests, including liver function, heart function, and complete blood cell counts, may be performed while you use Lapatinib. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. 
• PREGNANCY and BREAST-FEEDING: Lapatinib may cause harm to the fetus. Do not become pregnant while you are using it. It is not known if this medicine is found in breast milk. Do not breast-feed while taking this medicine.

This is not a complete list. Ask your health care provider for more information.

STORAGE REQUIREMENT : 

Store at room temperature of 25°C (77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).

DRUG INTERACTIONS : 

Some MEDICINES MAY INTERACT with Lapatinib Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, quinidine), arsenic, astemizole, bepridil, chloroquine, cisapride, dofetilide, dolasetron, domperidone, droperidol, halofantrine, haloperidol, iloperidone, ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), maprotiline, methadone, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quinolone antibiotics (eg, ciprofloxacin), tacrolimus, terfenadine, toremifene, or ziprasidone because the risk of a certain type of irregular heartbeat (QT prolongation) may be increased
• Atazanavir, azole antifungals (eg, itraconazole, ketoconazole, posaconazole), nefazodone, protease inhibitors (eg, boceprevir, indinavir, ritonavir), or voriconazole because they may increase the risk of Lapatinib’s side effects
• Carbamazepine, dexamethasone, hydantoins (eg, phenytoin), nevirapine, phenobarbital, primidone, rifamycins (eg, rifampin) or St. John’s wort because they may decrease Lapatinib’s effectiveness

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. 

ABOUT TYROGEF

Tyrogef is a type of drug called a tyrosine kinase inhibitor (TKI), also known as a cancer growth inhibitor. Kinases are proteins in the body that regulate how the cells grow and divide. Tyrogef blocks (inhibits) the protein from sending signals to the cancer cells that make them grow and divide.

TYROGEF USES

Tyrogef is used to treat some people with non-small cell lung cancer (NSCLC). It only works for cancers that have an abnormal form of a protein called epidermal growth factor receptor (EGFR). Tests are done on the cancer cells from a lung biopsy or previous surgery to check the level of EGFR.

TYROGEF SIDE EFFECTS :

Acne; diarrhea; dry skin; loss of appetite; mouth ulcers; nausea; unusual weakness; vision problems; vomiting; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the eyelids, mouth, face, lips, or tongue); cough; dark urine; dizziness; eye irritation or pain; extreme fatigue; fever; persistent diarrhea; stomach pain; swelling of the ankles or feet; yellowing of the skin or eyes.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

TYROGEF PRECAUTIONS:

    Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
    Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., pulmonary fibrosis), severe kidney disease, eye problems, stomach/intestinal ulcers, other stomach/intestinal problems (such as diverticulitis, blockage, bowel disease), smoking, cancer that has spread to the bowels.
    Gefitinib is not recommended for use during pregnancy. It may cause harm to an unborn baby. Consult your doctor for more details.
    It is not known whether this drug passes into breast milk. Due to the potential risk to the infant, breast-feeding while using gefitinib is not recommended.

This is not a complete list. Contact your doctor or pharmacist for more details.

PROPER STORAGE OF TYROGEF :

Store Tyrogef at 20°C to 25°C (68°F to 77°F). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Gefitinib out of the reach of children and away from pets.

TYROGEF INTERACTIONS :

    Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: “blood thinners” (warfarin), drugs which reduce stomach acid (e.g., ranitidine, cimetidine, famotidine, omeprazole, lansoprazole, rabeprazole), certain liver enzyme inhibitors (CYP 3A4 inhibitors such as ketoconazole, itraconazole, erythromycin, clarithromycin), vinorelbine, NSAIDs (such as ibuprofen, naproxen), corticosteroids (such as prednisone).
    Some liver enzyme inducer medications such as rifamycins (e.g., rifampin, rifabutin), St. John’s wort or phenytoin will stimulate certain liver enzymes (CYP 3A4). Your dosage of gefitinib may need to be increased if you are using such medications. Consult your doctor or pharmacist for more details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.