WHAT IS EMTRI-40?

Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells. Stavudine belongs to a group of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). It works by inhibiting the multiplication of viruses thus decreasing their levels in the infected patient. Nevirapine belongs to a class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Emtri-40 MEDICINE USES :

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Stavudine is used in combination with other anti-viral drugs in the treatment of Human Immunodeficiency Virus (HIV) infection. Nevarapine is used to treat and control Human Immunodeficiency Virus (HIV-1) infection for adults, adolescents, and children of any age. It must be used along with other HIV medicines.

LAMIVUDINE/STAVUDINE/NEVIRAPINE COMMON SIDE EFFECTS :

diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; or abnormal liver function tests.

Some people develop lactic acidosis while taking Lamivudine/Stavudine/ Nevirapine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as:

muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak;
stomach pain, nausea with vomiting; or fast or uneven heart rate.

Call your doctor at once if you have:

pancreas problems–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; or
liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for EMTRI-40 LAMIVUDINE/STAVUDINE/NEVIRAPINE TABLETS :

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Avoid pregnancy
Discontinue use if a rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin

Do not start using Nevirapine if you are allergic to it

Do not use if you are pregnant or breastfeeding

Do not use if you develop skin rash, blistering, mouth sores, swelling of the face, shortness of breath, muscle or joint pain or general feelings of illness
Have diabetes and renal impairment

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Lamivudine/Stavudine/Nevirapine Tablet may interact with the following drugs and products:

    Ketoconazole
    Methadone
    Oral contraceptives
    Rifabutin
    Rifampin
    St. John’s Wort

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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Cipla Entecavir Medicine Details 

Entecavir is used to treat chronic (long-term) hepatitis B infection (swelling of theliver caused by a virus) in people who have liver damage. Entecavir is in a class of medications called nucleoside analogs. It works by decreasing the amount ofhepatitis B virus (HBV) in the body

What are the side effects of entecavir?

Get emergency medical help if you have even mild symptoms of lactic acidosis, such as:

muscle pain or weakness;

numb or cold feeling in your arms and legs;

trouble breathing;

feeling dizzy, light-headed, tired, or very weak;

stomach pain, nausea with vomiting; or.

slow or uneven heart rate.

EPCLUSA Velpatasvir Sofosbuvir is a settled measurement mix tablet containing sofosbuvir and velpatasvir for oral organization. Sofosbuvir is a nucleotide simple HCV NS5B polymerase inhibitor and velpatasvir is a NS5A inhibitor. 

Every tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. The tablets incorporate the accompanying dormant fixings: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are film-covered with a covering material containing the accompanying inert fixings: press oxide red, polyethylene glycol, polyvinyl liquor, powder, and titanium dioxide. 

Signs 

EPCLUSA is demonstrated for the treatment of grown-up patients with perpetual hepatitis C infection (HCV) genotype 1, 2, 3, 4, 5, or 6 contamination [see DOSAGE AND ADMINISTRATION and Clinical Studies]: 

without cirrhosis or with remunerated cirrhosis 

with decompensated cirrhosis for use in blend with ribavirin 

Dose AND ADMINISTRATION 

Testing Prior To The Initiation Of Therapy 

Test all patients for confirmation of present or earlier HBV contamination by measuring hepatitis B surface antigen (HBsAg) and hepatitis B center counter acting agent (against HBc) before starting HCV treatment with EPCLUSA [see WARNINGS AND PRECAUTIONS]. 

Prescribed Dosage 

The prescribed measurement of EPCLUSA is one tablet brought orally once every day with or without nourishment. One tablet of EPCLUSA contains 400 mg of sofosbuvir and 100 mg of velpatasvir. Table 1 demonstrates the prescribed treatment regimen and span in light of patient populace.