WHAT IS EGYMELAN?

EGYMELAN 50mg is one of a group of drugs called alkylating agents. It
sticks to one of the cancer cell’s DNA strands. DNA is the genetic code that is
in the nucleus of all animal and plant cells. It controls everything the cell
does. The cell cannot then grow and divide into 2 new cells.

MEDICINE USES :

Melphalan is used to treat multiple myeloma (a type of blood cancer),
advanced breast cancer and cancer of the ovary. This medicine treats only the
symptoms of ovarian cancer or multiple myeloma, but does not treat cancer
itself.

MELPHALAN COMMON SIDE
EFFECTS :

missed menstrual periods; weakness; or temporary hair loss.

Call your doctor at once if you have:

bone marrow suppression–sudden weakness or ill feeling, fever, chills,
pale skin, easy bruising or bleeding, red or pink urine, painful mouth sores,
cough, trouble breathing, feeling light-headed, rapid heart rate;

inflammation of your blood vessels–numbness or tingling, red skin rash,
unusual lumps or masses, fever, weight loss, muscle or joint pain, tired
feeling, unusual bleeding; or

liver problems – nausea, upper stomach pain, itching, loss of appetite,
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects.

SAFETY INFORMATION
(Precautions) for EGYMELAN MELPHALAN INJECTION :

Egymelan may lower the ability of your body to fight infection. Avoid
contact with people who have colds or infections. Tell your doctor if you
notice signs of infection like fever, sore throat, rash, or chills.

Do not receive a live vaccine (eg, measles, mumps) while you are taking
Melphalan. Talk with your doctor before you receive any vaccine.

Use of Egymelan may increase your risk of developing another type of
cancer. The risk may be greater if you use higher doses of this medicine or if
you use it for a longer period of time. Discuss any questions or concerns with
your doctor.

Egymelan may affect the ovaries. This may cause irregular or absent
menstrual periods and decreased fertility in some women. Discuss any questions
or concerns with your doctor.

Egymelan may affect the testicles and cause decreased fertility in some
men. This may be permanent in some patients. Discuss any questions or concerns
with your doctor.

PREGNANCY and BREAST-FEEDING: Melphalan has been shown to cause harm to
the fetus. Avoid becoming pregnant while taking it. If you think you may be
pregnant, contact your doctor. You will need to discuss the benefits and risks
of using this medicine while you are pregnant. It is unknown if Generic
Melphalan is found in breast milk. Do not breast-feed while taking it.

This is not a complete list. Ask your health care provider for more
information.

MEDICATION STORAGE
REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Tell your health care provider if you are taking any other medicines,
especially any of the following:



    Cisplatin because the risk of Melphalan’s side effects
may be increased

    Carmustine (BCNU), cyclosporine, or nalidixic acid
because serious lung, kidney, or bowel problems may occur

    Palifermin because if mouth or tongue sores develop,
they may be more severe or last longer



This may not be a complete list of all interactions that may occur. Ask
your health care provider if Melphalan may interact with other medicines that
you take.

WHAT IS EMDUO-30 TABLETS?

Lamivudine prevents
the multiplication of HIV virus in human cells. Thus stops the HIV virus from
producing new viruses.

Lamivudine belongs to a class of medication
called nucleoside reverse transcriptase inhibitors. It decreases the amount of
virus (HIV and hepatitis) in the blood. It also increases the number of
infection fighting cells in the body (CD 4 cells. Stavudine belongs to a group
of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). It
works by inhibiting multiplication of viruses thus decreasing their levels in
the infected patient.

MEDICINE USES:

Lamivudine indicated as part of antiviral
combination therapy for the treatment of Human Immunodeficiency Virus (HIV)
infected adults and children and also used in the treatment of Hepatitis B
virus infection. Stavudine is used in combination with other anti-viral drugs
in the treatment of Human Immunodeficiency Virus (HIV) infection.

Emduo E 30 Kit is used for HIV, Suppression of immunity, Cancer, Infections,
HIV infection, Hepatitis b virus infection and other conditions. Emduo E 30
Kit may also be used for purposes not listed in this medication guide.

Emduo E 30 Kit contains Efavirenz, Lamivudine, and Stavudine as
active ingredients.

Emduo E 30 Kit works by inhibiting multiplication of viruses;
blocking RNA-dependent DNA polymerase function in viral DNA replication;
increasing the number of infection-fighting cells in the body.

EMDUO-30 COMMON SIDE EFFECT:

On
using this medication you may experience side effects such as nausea, joint pain, difficulty
sleeping, diarrhea, cough, dizziness, swelling of the mouth, headache, reduced
appetite, weakness, vomiting,
darkening of the urine, numbness,
mental/ mood disorders, ear pain,
itchiness, sore throat and chest
pain. If your reactions persist or worsen over time
seek the help of your health care provider right away.

The following is a list of possible side-effects that may occur from all constituting ingredients of Emduo
E 30 Kit. This is not a comprehensive list. These
side-effects are possible, but do not always occur. Some of the side-effects
may be rare but serious. Consult your doctor if you observe any of the
following side-effects, especially if they do not go away.

Some
people develop lactic acidosis while taking lamivudine/Stavudine. Early
symptoms may get worse over time and this condition can be fatal. Get emergency
medical.

Muscle
pain or weakness; numb or cold feeling in your arms and legs; trouble breathing,
feeling dizzy, light-headed, tired, or very weak.
Stomach
pain, nausea with vomiting or fast or uneven heart rate.

Get emergency medical help if you have signs of
an allergic reaction: hives; difficult breathing, swelling of your face, lips,
tongue, or throat.

EMDUO-30 TABLETS- DRUG PRECAUTIONS:

Before
using Emduo E 30 Kit, inform your doctor about your current list of
medications, over the counter products (e.g. vitamins, herbal supplements,
etc.), allergies, pre-existing diseases, and current health conditions (e.g.
pregnancy, upcoming surgery, etc.). Some health conditions may make you more
susceptible to the side-effects of the drug. Take as directed by your doctor or
follow the direction printed on the product insert. Dosage is based on your
condition. Tell your doctor if your condition persists or worsens. Important
counseling points are listed below.

Always taken in combination with other
anti-HIV medicines and never alone

Any signs of skin rash or inflammation or
infection

Avoid drinking alcohol

Avoid driving and operating heavy machinery
if you experience dizziness from taking this medication

Avoid pregnancy

Children

EMDUO-30 TABLETS- DRUG INTERACTIONS: 

If you use other drugs or
over the counter products at the same time, the effects of Emduo E 30 Kit may
change. This may increase your risk for side-effects or cause your drug not to
work properly. Tell your doctor about all the drugs, vitamins, and herbal
supplements you are using, so that your doctor can help you prevent or manage
drug interactions. Emduo E 30 Kit may interact with the following
drugs and products:

Ativan

Ergostat

Indinavir

Norvir

Saquinavir

Sulfamethoxazole