产品介绍:

普纳替尼（Ponatinib），是第三代BCR-ABL酪氨酸激酶抑制剂（TKIs）。2012年12月14日，普纳替尼被美国FDA 特许经过快速审批上市销售，用于ABL T315I突变的慢性粒细胞白血病（CML）或费城染色体阳性（Ph+）的急性淋巴细胞白血病（ALL）的治疗，也可用于对以往酪氨酸激酶抑制剂 （TKI）耐药或不耐受的CML 或ALL的治疗。

尽管第一代、二代TKIs改善了CML及Ph+ALL患者的临床结局，但耐药仍发生在一些BCR-ABL突变患者中，尤其是T315I突变。在第三代TKIs普纳替尼获批之前，市场上没有TKIs能克服这些BCR-ABL突变患者耐药、难治或不耐受的情况。在加速期CML、急变期CML和Ph+急淋患者中，普纳替尼取得的主要血液学反应率分别为55%、31%和41%。因此，普纳替尼是一种强有效的口服TKIs，对于难治性的CML患者，尤其有T315I突变的患者来说，该药成为非常重要的临床选择。

在普纳替尼 Ph + ALL和CML评估（PACE）试验中接受单药普纳替尼治疗的患者与欧洲骨髓移植登记处报告的allo-SCT患者OS的事后、回顾性、间接比较，CML分层进行了疾病阶段和Ph + ALL。 Kaplan-Meier生存曲线和多变量Cox比例风险模型用于比较干预组之间的OS，调整从诊断到干预的时间、年龄、性别和地理区域，报告了24个月和48个月的OS率和中位OS。

服用普纳替尼需注意充血性心衰、高血压、胰腺炎、出血、心律失常、患者身体的各项数据。充血性心衰：监视患者充血性心衰的体征和症状和临床有指针时治疗。高血压：监视高血压和临床有指针时治疗。胰腺炎：每月监视血清酯酶；中断或终止普纳替尼。出血：对严重出血中断普纳替尼，液体潴留：监视患者是否液体潴留； 中断或终止普纳替尼。

碧康制药生产的Ponatinix是普纳替尼在全球的首仿药，也是迄今为止唯一获得政府监管机构批准合法生产的仿制药。

碧康制药由欧洲财团参与投资，是南亚地区唯一执行欧盟技术规范，并且在孟加拉两大证券交易所主板上市的大型制药企业，产品符合欧洲药典和美国药典标准。

相比其他来源不清晰的所谓同一种仿制药，即使其主要成份含量与碧康产品相接近，但由于不具备严格规范的GMP标准生产场所和政府部门的严格监管，其产品中影响药物吸收率的溶出度和生物利用度也与碧康产品具有很大差异。 为保证用药安全，敬请谨慎选择！

适应症:

适用于为治疗对既往酪氨酸激酶抑制剂治疗耐药或不能耐受的有慢性相，加速相，或母细胞相慢性粒性白血病(CML)成年患者。

用法与用量:

推荐剂量是45mg，每天1次，有或无食物口服；

只要没有出现疾病进展或不可接受的毒性证据，应继续治疗；

对血液学和非-血液学毒性调整剂量或中断给药。

常见不良反应：

最常见非血液学不良反应(≥20%)是高血压，皮疹，腹痛，疲乏，头痛，干皮肤，便秘，关节痛，恶心，和发热。血液学不良反应包括血小板减少，贫血，中性粒细胞减少，淋巴细胞减少，和白细胞减少。

特殊人群中使用：

充血性心衰：监视患者充血性心衰的体征和症状和临床有指针时治疗。

高血压：监视高血压和临床有指针时治疗。

胰腺炎：每月监视血清酯酶； 中断或终止服药。

出血：对严重出血中断服药。

液体潴留：监视患者液体潴留，应中断，或降低剂量，乃至终止服药。

心律失常：监视心律失常的症状。

骨髓抑制：血小板减少，中性粒细胞减少，和贫血可能需要中断或减低剂量。每两周监视全细胞计数共3个月和然后每月和当临床上指示。对ANC < 1000/mm3或血小板减少 < 50000/mm3中断服药。 肿瘤溶解综合征：开始用普纳替尼治疗前确保水化和纠正高尿酸水平。

伤口愈合受到损害和胃肠道穿孔：在接受大型手术患者中短暂中断治疗。

胚胎-胎儿毒性：可能致胎儿危害。劝告妇女对胎儿的潜在风险。

What is Posid Etoposide Capsules for:

This medication is an anti-cancer agent, prescribed for lung cancer and testicular cancer. It slows or stops the growth of cancer cells.

How should Posid Etoposide Capsules be used:

Testicular cancer- Adult: IV- The recommended dose is 50-100 mgm2day from days 1-5. Small cell lung cancer- The recommended dose is 35 mgm2day for 4 days to 50 mgm2day for 5 days. May repeat course 3-4 weekly. Testicular cancer- Adult: IV- The recommended dose is 50-100 mgm2day from days 1-5. Small cell lung cancer- The recommended dose is 35 mgm2day for 4 days to 50 mgm2day for 5 days. May repeat course 3-4 weekly. It comes as a solution for injection to be administered by a healthcare provider into the vein on an empty stomach. It comes as a solution for injection to be administered by a healthcare provider into the vein on an empty stomach.

Common side effects of Posid Etoposide Capsules:

Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Anemia, low white blood cell count, and low platelet count. Feeling tired or weak. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Irritation or swelling where the shot was given. Hair loss. Hair most often grows back when this drug is stopped. May not be able to get pregnant. Flushing and low blood pressure can happen if the shot is given too fast. Unsafe allergic effects may rarely happen.

What precautions should I take when taking Posid Etoposide Capsules:

If you have an allergy to Posid Etoposide Capsulesor any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are pregnant or may be pregnant. If you are breast-feeding.

Can I take Posid Etoposide Capsules with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. – Taking them together can cause bad side effects. – Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

 store Posid Etoposide Capsules:

Store it in refrigerator (2-8°C), do not freeze.

Poxet 60mg Dapoxetine Tablet Description:

Poxet 60mg Tablet is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the level of serotonin in nerve thereby increasing the time it takes to ejaculate and can improve the control over ejaculation.

Uses:

Poxet 60mg Tablet is used in the treatment of premature ejaculation. It should be used in men of 18 to 64 years of age.

Side Effects:

Nausea, Headache, Dizziness.

Dosage:

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Poxet 60mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

FAQs

Does Poxet cure premature ejaculation?
Poxet is used to treat premature ejaculation in adult men aged 18 to 64 years. Premature ejaculation is when a man ejaculates with little sexual stimulation and before the man wants. This can cause problems for the man and may cause problems in sexual relationships.

What does Poxet do?
Poxet increases the time it takes to ejaculate and can improve the control over the ejaculation. This may reduce the frustration or worry about fast ejaculation. Poxet is used to treat premature ejaculation in adult men aged 18 to 64 years.

Is Poxet a prescription drug?
Yes, Poxet is a prescription drug, it is not an over the counter product.

Is Poxet safe?
Poxet is safe if used at prescribed doses for the prescribed duration as advised by your doctor.