WHAT IS LOPIMUNE?

Lopinavir belongs to the class of medications called as antiretroviral agents. It works by inhibiting HIV viral protease enzyme and inhibiting viral replication (multiplication) thereby preventing the infection. Ritonavir belongs to a class of medication called protease inhibitors. It prevents HIV from multiplying inside the body.

MEDICINE USES :

Lopinavir is used to treat human immunodeficiency virus (HIV) infection. It is always used in combination with other drugs used for the treatment of HIV. Ritonavir is used along with other medications for treating human immunodeficiency virus (HIV 1) infection.

LOPINAVIR/RITONAVIR COMMON SIDE EFFECTS :

nausea, vomiting, diarrhea; high cholesterol; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Call your doctor at once if you have:

    severe pain in your upper stomach spreading to your back, nausea, and vomiting;
    itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
    penis erection that is painful or lasts 4 hours or longer (if you take Lopinavir with erectile dysfunction medication);
    muscle weakness, tired feeling, joint or muscle pain, feeling short of breath; or
    signs of a new infection–fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;
    chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;
    cold sores, sores on your genital or anal area;
    rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;
    trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or
    swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for LOPIMUNE LOPINAVIR/RITONAVIR TABLETS :

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

    Children
    Consult a doctor if you have hemophilia or pancreatitis
    Have high cholesterol or triglyceride levels, hemophilia or another bleeding disorder
    History of kidney problems, liver problems, pancreas problems, diabetes, low potassium or magnesium blood levels, heart problems, heart blood vessel problems, or irregular heartbeat
    Monitor glucose, lipid, and uric acid regularly
    Pregnancy

MEDICATION STORAGE REQUIREMENTS :

Store at 20°C to 25°C (68°F to 77°F). Exposure to high humidity outside of the original container for >2 weeks is not recommended.

DRUG INTERACTIONS :

Many drugs can interact with Lopimune. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

    antiviral medicines to treat hepatitis C or HIV;
    cancer medicine;
    medicine to prevent organ transplant rejection;
    an antibiotic–bedaquiline, clarithromycin, metronidazole, rifabutin;
    antifungal medicine–itraconazole, ketoconazole, voriconazole;
    heart or blood pressure medicine–amiodarone, felodipine, lidocaine, nicardipine, nifedipine, quinidine;
    medicine to prevent blood clots–rivaroxaban, warfarin (Coumadin, Jantoven);

Lorbrexen 100 Mg (Lorlatinib), Generic Lorbrena is a prescription medicine that is used to treat metastatic non-small cell lung cancer in patients who have a certain type of abnormal anaplastic lymphoma kinase (ALK) gene. It is used in patients who have already received alectinib, ceritinib, or both crizotinib and at least 1 other medicine to treat NSCLC that is caused by the ALK gene.

适应症:

Lorlatinib是一种激酶抑制剂，用于治疗转移性非小细胞肺癌（NSCLC）的成人患者，其肿瘤经FDA批准的试验检测为间变性淋巴瘤激酶（ALK）阳性。

推荐剂量:

推荐剂量：口服100mg，每日1次

严重肾损害：口服75mg，每日1次。

不良反应:

最常见的不良反应（发生率≥20%）是水肿、周围神经病变、认知影响、呼吸困难、疲乏、体重增加、关节痛、情绪影响和腹泻。

最常见（发生率≥20%）的不良反应和3-4级实验室异常是水肿、周围神经病变、体重增加、认知功能影响、疲劳、呼吸困难、关节痛、腹泻、情绪影响、高胆固醇血症、高甘油三酯血症和咳嗽。

服用方法:

劳拉替尼的推荐剂量是口服100毫克每日一次，可与或不与食物同服，直到病情恶化或不可接受的毒性反应。

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