Here are Harvoni (Ledipasvir/sofosbuvir) costs in :

– the US ($94,500)

– Canada ($80,000)

– India ($900)

– the UK (£39,000)

– Germany (48,000€)

– Egypt ($1200)

This medicine is a mix of ledipasvir and sofosbuvir and is utilized to treat incessant (durable) hepatitis C, a viral contamination of the liver. It might once in a while be utilized with another antiviral medicine (ribavirin). These medications work by lessening the measure of hepatitis C infection in your body, which enables your insusceptible framework to battle the contamination and may enable your liver to recuperate. Endless hepatitis C contamination can cause genuine liver issues, for example, scarring (cirrhosis), or liver tumor. 

It is not known whether this treatment can keep you from passing the infection to others. Try not to share needles, and practice “more secure sex” (counting the utilization of latex condoms) to bring down the danger of passing the infection to others. 

Step by step instructions to utilize Harvoni 

Read the Patient Information Leaflet if accessible from your drug specialist before you begin taking ledipasvir/sofosbuvir and each time you get a refill. On the off chance that you have any inquiries, ask your specialist or drug specialist. 

Take this pharmaceutical by mouth with or without nourishment as coordinated by your specialist, ordinarily once every day. 

This pharmaceutical works best when the measure of medication in your body is kept at a steady level. In this way, take this medication at uniformly divided interims. To enable you to recollect, take it in the meantime every day. 

Tell your specialist on the off chance that you upchuck inside 5 hours in the wake of taking this prescription. You may need to take another dosage. 

Keep on taking ledipasvir/sofosbuvir for the full timeframe endorsed, regardless of the possibility that manifestations vanish a little while later. Ceasing the medicine too soon may bring about an arrival of the disease. 

Acid neutralizers bring down the retention of ledipasvir. On the off chance that you are taking an acid neutralizer, take it no less than 4 hours earlier or 4 hours after this prescription. 

Other corrosive bringing down meds for acid reflux, indigestion, or ulcers, (for example, medicine or over-the-counter meds including famotidine, omeprazole) may keep ledipasvir from working. Ask your specialist or drug specialist how to utilize these medicines securely.

Doses & Administration

Each tablet contains 90 mg ledipasvir and 400 mg sofosbuvir. Tablets include the following inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. These tablets are film-coated with a coating material containing the following inactive ingredients: FD&C yellow #6/sunset yellow FCF aluminum lake, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

It is indicated with or without ribavirin for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1, 4, 5, or 6 infection.

Harvoni Side Effects:

If Harvoni is administered with ribavirin, refer to the prescribing information for ribavirin for a description of ribavirin-associated adverse reactions. The safety assessment was based on pooled data from three randomized, open-label Phase 3 clinical trials (ION-3, ION-1 and ION-2) of subjects with genotype 1 HCV with compensated liver disease (with and without cirrhosis) including 215, 539, and 326 subjects who received once daily by mouth for 8, 12 and 24 weeks, respectively.

The proportion of subjects who permanently discontinued treatment due to adverse events was 0%, less than 1%, and 1% for subjects receiving these tablets for 8, 12, and 24 weeks, respectively.

The most common adverse reactions (at least 10%) were fatigue and headache in subjects treated with 8, 12, or 24 weeks of Harvoni.

Potential For Drug Interaction

As Harvoni contains ledipasvir and sofosbuvir, any interactions that have been identified with these agents individually may occur with tablets.

After oral administration of tablets, sofosbuvir is rapidly absorbed and subject to extensive first-pass hepatic extraction. In clinical pharmacology studies, both sofosbuvir and the inactive metabolite GS-331007 were monitored for purposes of pharmacokinetic analyses. Ledipasvir is an inhibitor of the drug transporters P-gp and breast cancer resistance protein (BCRP) and may increase intestinal absorption of coadministered substrates for these transporters.

Ledipasvir and sofosbuvir are substrates of drug transporters P-gp and BCRP while GS-331007 is not. P-gp inducers (e.g., rifampin or St. John’s wort) may decrease ledipasvir and sofosbuvir plasma concentrations, leading to reduced therapeutic effect of Harvoni, and the use with P-gp inducers is not recommended with Harvoni.

TAF，替诺福韦二代。　新药彻底治愈乙肝不可能，但能实现临床治愈。 　　TAF能实现临床治愈，是目前乙肝治疗界公认的最高水平。　什么是临床治愈?又为什么治愈不可能?摊开来讲好比将军带兵攻打敌国，大败敌军生擒国王，将其下监，严加看管，此后四海之内再无敌军，这就是临床治愈。但这国王装疯卖傻以求活命，并仍有一定的可能在守卫疏忽之时越狱，东山再起，这就是无法完全治愈。　　TAF作为替诺福韦第二代，几乎没有肾毒性，取代替诺福韦TDF是早晚的问题。

具体表现在：　　

1.更好的骨骼安全性　　2.更好的肾脏安全性　　3.耐药性最低　　4.十分之一剂量，可达到国内一线治疗药物TDF的同等药效　　我适合服用TAF吗? 　　

TAF并非适合每一个乙肝患者，

它更加适合以下患者：　　

1.首次服用抗病毒药物的乙肝患者　　2.在服用其他抗病毒药物的患者，更换药物时需询问医生　　3.服用其他药物时，在3年内产生耐药性的，强烈推荐　　4.为预防乙肝妈妈将病毒传给宝宝，哺乳期妇女建议使用　　5.还患有糖尿病或肾损伤、骨质疏松严重的患者. 

 ABOUT HEPCDAC

HEPCDAC (Daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

MEDICINAL USES :

Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

HEPCDAC COMMON SIDE EFFECTS :

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

SAFETY INFORMATION (Precautions) :

    Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
    Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease other than hepatitis C.
    Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
    During pregnancy, daclatasvir should be used only when clearly needed. Discuss the risks and benefits with your doctor. Daclatasvir, in combination with ribavirin, must not be used during pregnancy by either the pregnant woman or her male partner. The combination may harm an unborn baby. Two reliable forms of birth control (such as condoms, birth control pills) must be used whenever at least one sexual partner is using these medicines together, and for six months after stopping treatment. If you or your partner becomes pregnant, or if you think you or your partner may be pregnant, tell your doctor right away.
    It is unknown if daclatasvir passes into breast milk. Consult your doctor before breast-feeding. Breast-feeding is not recommended if daclatasvir is used in combination with ribavirin.

PROPER STORAGE OF HEPCDAC :

Store at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F and 86°F).

HEPCDAC INTERACTIONS :

Amiodarone may interact with sofosbuvir. Tell your doctor and pharmacist if you are taking amiodarone.

Other medications can affect the removal of daclatasvir from your body, which may affect how daclatasvir works. Examples include rifampin, St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Natco company has launched a hard and fast dose combination of Sofosbuvir-Daclatasvir tablets for the treatment of viral hepatitis underneath the brand Hepcinat and in India.The product could be a generic fastened dose combination of Sofosbuvir four hundred mg and Daclatasvir 60mg tablets used for the treatment of patients with chronic viral hepatitis infection, Get Hepcinat Plus Wholesale Cost In India , WeChat:LetsMeds , 

ABOUT HEPCVEL

Hepcvel medication is a combination of sofosbuvir and velpatasvir. This drug work by reducing the amount of hepatitis C Virus in your body, which helps your immune system fight the infection and may help your liver recover.

MEDICINE USES :

Cipla’s Sofosbuvir and Velpatasvir is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It may sometimes be used with another antiviral medication (ribavirin).

Velpatasvir Sofosbuvir Tablets works:-

Take this prescription by mouth with or
without sustenance as coordinated by your specialist, for the most part once
daily.This solution works best when the measure of medication in your body is
kept at a consistent level. Take this medication at equally divided interims.
To enable you to recollect, take it in the meantime every day.

Keep on taking sofosbuvir/velpatasvir for the
full timeframe endorsed, regardless of whether manifestations vanish a little
while later. Halting the drug too soon may bring about an arrival of the
infection.

Velpatasvir Sofosbuvir Tablets Side Effects:

·       Common Hepcvel side effects may include:

    headache;
    tired feeling;
    nausea, diarrhea; or
    sleep problems (insomnia).
    slow heartbeats;
    weak or shallow breathing; or
    low red blood cells-pale skin, weakness, rapid heart rate, trouble concentrating.

If you also take amiodarone: Seek medical help right away if you feel weak, tired, or light-headed, or if you have chest pain, shortness of breath, confusion, or memory problems.

      Keep in mind that your specialist has endorsed this prescription since he or she has judged that the advantage to you is more prominent than the danger of reactions. Numerous individuals utilizing this prescription don’t have       genuine reactions.

·         Tell your specialist immediately in the event that you have any genuine symptoms, including: mental/state of mind changes, (for example, wretchedness), irregular tiredness.

·         An intense unfavorably susceptible response to this medication is uncommon. Be that as it may, get restorative help immediately in the event that you see any side effects of a genuine unfavorably susceptible response, including:    rash, tingling/swelling (particularly of the face/tongue/throat), extreme wooziness, inconvenience relaxing.

·         This isn’t a total rundown of conceivable reactions. On the off chance that you see different impacts not recorded above, contact your specialist or drug specialist.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Precautions
and warning:-

To make sure Cipla Hepcvel is safe for you, tell your doctor if you have:

    a history of hepatitis B;
    kidney disease (or if you are on dialysis);
    liver problems other than hepatitis;
    HIV (human immunodeficiency virus); or
    if you have recently used a heart rhythm medicine called amiodarone.

It is not known whether Hepcvel will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

During pregnancy, this
solution ought to be utilized just when unmistakably required. Talk about the
dangers and advantages with your specialist. Sofosbuvir / velpatasvir, in blend
with ribavirin, must not be utilized during pregnancy by either the pregnant lady or her
male accomplice. The mix may hurt an unborn child.

It is not known whether sofosbuvir and velpatasvir passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

This is not a complete list. Ask your health care provider for more information.    

MEDICATION STORAGE REQUIREMENTS :

Store below 30 °C (86 °F). Dispense only in the original container.

Sofosbuvir and Velpatasvir DRUG INTERACTIONS : 

Many drugs can interact with sofosbuvir and velpatasvir. Tell your doctor about all your current medicines and any you start or stop using, especially:

    amiodarone;
    St. John’s wort;
    any medicine that contains tenofovir
    cholesterol medication such as atorvastatin or rosuvastatin;
    other antiviral medicines such as efavirenz, ritonavir, or tipranavir; or
    tuberculosis medication-rifabutin, rifampin, rifapentine.

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.