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  • ( reviews)

    Briganix 布加替尼 Tablets

    $50.00

    产品介绍:

    布加替尼(Brigatinib,又译为:布吉他滨或布格替尼,研发代号:AP26113)是一款酪氨酸激酶强效抑制剂。2017年4月28日,布加替尼获美国FDA加速批准上市,用于治疗在克唑替尼治疗后病情出现进展或不耐受的ALK阳性的局部晚期或静态非小细胞肺癌的患者。布加替尼能抑制ALK以及ALK融合蛋白,从而抑制肿瘤的生长。在体外与体内试验中,布加替尼均彰显了良好的抑制效果。因此,它也曾先后获得过美国FDA 颁发的突破性疗法认定与孤儿药资格。

     布加替尼克服ALK突变体导致的对克唑替尼的抗性,具有抗多种激酶(包括ALK、ROS1、胰岛素样生长因子-1受体、Flt-3)以及表面生长因子受体(EGFR)缺失和点突变的活性。布加替尼对ALK的抑制作用比克唑替尼高12倍,对ALK突变体有很高的抗性,故而可以用于治疗克唑替尼治疗后病情进展或不耐受的ALK阳性的转移性非小细胞肺癌患者。

     临床研究结果证实,布加替尼联合抗EGFR抗体使用或可突破第三代靶向药奥希替尼(AZD9291)的耐药,可强效抑制ALK的L1196M突变和EGFR的T790M突变。

     布加替尼不仅对T790M双突变非小细胞肺癌具有一定功效,而且对C797S / T790M / del19三重突变细胞以及T790M / del19双突变细胞也有活性。因此,布加替尼很可能因为克服C797S突变耐药,而成为“第四代EGFR-TKI肺癌靶向药”,用于第三代靶向药奥希替尼耐药后的治疗。

     对于已发生中枢神经系统脑部转移的患者,服用色瑞替尼的患者45%有脑部病灶应答,艾乐替尼则64%患者有脑部病灶应答。而服用标准剂量的布加替尼脑部应答率高达67%,脑部病灶中位无进展生存时间PFS达到18.4个月。

     碧康制药生产的Briganix是布加替尼在全球的首仿药,也是迄今为止唯一获得政府监管机构批准合法生产的仿制药。

     碧康制药由欧洲财团参与投资,是南亚地区唯一执行欧盟技术规范,并且在孟加拉两大证券交易所主板上市的大型制药企业,产品符合欧洲药典和美国药典标准。

     相比其他来源不清晰的所谓同一种仿制药,即使其主要成份含量与碧康产品相接近,但由于不具备严格规范的GMP标准生产场所和政府部门的严格监管,其产品中影响药物吸收率的溶出度和生物利用度也与碧康产品具有很大差异。

     为保证用药安全,敬请谨慎选择!

    适应症:

    用于治疗间变性淋巴瘤激酶(ALK)阳性非小细胞肺癌,且在克唑替尼(Crizotinib)治疗后病情出现进展或不耐受的患者。

    用法与用量:

    1、口服,每日一次,从每次90mg起始剂量开始服用,连续服用7日;

    2、若无严重副作用或不耐受,7日后剂量调整为每日180mg,每日一次。

    3、若因不良反应以外的其他原因(如漏服或用药后呕吐)导致暂停用药14日或14日以上,重新用药时,应先按每次90mg、每日1次,连用7日,再增至之前耐受的剂量。

    4、应整片吞服,不可压碎或咀嚼,可与或不与食物同服。

    5、治疗期间,要避免进食一些食物,也要避免服用可能会产生相互作用的一些药物,包括:葡萄柚,葡萄柚汁,酮康唑,利福平,苯妥英,圣约翰草和激素节育药物等。

     特殊人群的使用:

    哺乳妇女应停止哺乳或停药。

     常见副作用:

    恶心、呕吐、腹泻、便秘、食欲下降、疲劳、头痛、发热、咳嗽、肌肉痛、关节痛、高血糖等。

  • ( reviews)

    CA ATRA 10 Mg Softgel Capsules

    $50.00

    WHAT IS CA ATRA 10 MG CAPSULES ?

    Ca atra is a capsule composition of All-Trans Retinoic Acid
    (Tretinoin) which works by promoting the growth of normal, mature cells in the
    bone marrow and blood. Tretinoin comes in a class of drugs known as retinoids,
    which are related to vitamin A.

    WHAT IS THE USE OF CA ATRA 10 MG CAPSULES ?

    Tretinoin
    is used with other medications to treat a certain type of cancer of the white
    blood cells (APL-acute promyelocytic leukemia).

    WHAT ARE THE POSSIBLE SIDE-EFFECTS OF CA ATRA 10 MG CAPSULES ?

    Headache,
    dizziness, fever, weakness, tiredness, dry mouth, dry skin, other skin changes,
    thinning hair, nausea, vomiting, itching, bone pain, mouth sores, increased
    sweating, and earache may occur.

    Tell your
    doctor right away if any of these unlikely but serious side effects occur:
    stomach/abdominal pain, yellowing eyes/skin, dark urine, hearing problems
    (e.g., hearing loss), signs of kidney problem, mental/mood changes, asft/slow/irregular
    heartbeat.

    This is not a complete list of all side effects
    that may occur. If you have questions about side effects, contact your health
    care provider. Call your doctor for medical advice about side effects.

    WHAT IS THE IMPORTANT SAFETY INFORMATION OF CA ATRA 10 MG CAPSULES?


    • Before taking Tretinoin, tell
      your doctor if you are allergic to it.
    • Before using this medication,
      tell your doctor your medical history.
    • This medication is not
      recommended for use during pregnancy due to the risk of birth defects and
      harm to an unborn baby.
    • Because of the possible risk to
      the infant, breast-feeding while using this drug is not recommended.

     

  • ( reviews)

    Cabozanib Cabozantinib Tablet

    $50.00

    Cabozanib Cabozantinib Tablets

    Cabozantinib Tablet is a chemotherapy drug sold under the brand name Cabozanib, which is used to treat medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. 


    What does cabozantinib do and what do I use it for?

    Cabozantinib is a tyrosine kinase inhibitor . This is a targeted cancer-inhibiting substance (‘targeted therapy’).

    Doctors prescribe it for a certain form of thyroid cancer and for renal cell cancer .


    Side of Generic Cabozantinib Tablet:

    Nausea, vomiting, loss of hunger, fatigue, oral pain, mouth sores, dry skin, diarrhea, low calcium, high blood pressure, taste change, hand-foot syndrome. On the off chance that any of these impacts continue or decline, inform your specialist or drug specialist expeditiously. 

    Tell your specialist immediately if any of these uncommon yet intense symptoms happen: indications of kidney issues, (for example, change in the measure of pee), dark stools, upchuck that resembles espresso beans, simple dying/wounding, stomach/stomach pain, yellowing eyes or skin, dim pee, surprising weakness, indications of contamination (e.g., fever, chills, tenacious sore throat), eye pain, vision changes. 


    Where to buy Generic Cabozantinib Tablet Cabozanib at Wholesale Price from India?

    LetsMeds Trusted Medicine Exporter provides #Indian #Cabozantinib Tablet sold under the brand name #Cabozanib made by BDR and its other generic brands at wholesale price with delivery to countries over 220+ including China, USA, UAE, Russia, Singapore, Canada, Hong Kong, UK, Romania, Malaysia, Nepal, Japan, Vietnam, Poland, Philippines, Japan, and many other countries. If you wish to order #Cabozantinib Brands at Wholesale Price, and send them overseas you just need to fill the “Ask For Price” form and contact us. We will get in touch with you shortly as your order gets placed.

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