Lamivir (Stavudine and Lamivudine) Tablets

WHAT IS LAMIVIR S-40 ?

Lamivudine  belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells. Stavudine belongs to a group of drugs called as nucleoside reverse transcriptase inhibitors (NRTIs). It works by inhibiting multiplication of viruses thus decreasing their levels in the infected patient.

MEDICINE USES :

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Stavudine is used in combination with other anti-viral drugs in the treatment of Human Immunodeficiency Virus (HIV) infection.

LAMIVUDINE/STAVUDINE COMMON SIDE EFFECTS :

diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; or abnormal liver function tests.

Some people develop lactic acidosis while taking Lamivudine/Stavudine. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as:

    muscle pain or weakness; numb or cold feeling in your arms and legs; trouble breathing; feeling dizzy, light-headed, tired, or very weak;
    stomach pain, nausea with vomiting; or fast or uneven heart rate.

Call your doctor at once if you have:

    pancreas problems–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; or
    liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

SAFETY INFORMATION (Precautions) for LAMIVIR S-40 LAMIVUDINE/STAVUDINE TABLETS :

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

    Avoid drinking alcohol
    Avoid pregnancy
    Consult a doctor if you have liver or kidney disease or metabolic or lactic acidosis or peripheral neuropathy
    Discontinue use if rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin
    Have diabetes and renal impairment
    Pregnancy

This is not a complete list. Ask your health care provider for more information.

MEDICATION STORAGE REQUIREMENTS :

Store at 20° to 25°C (68° to 77°F).

DRUG INTERACTIONS :

Lamivir S Tablet may interact with the following drugs and products:

    Sulfamethoxazole
    Trimethoprim
    Zidovudine

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.