ADRIAMYCIN Doxorubicin
Injection:

Adriamycin is a cancer medication that interferes with the
growth and spread of cancer cells in the body. It is classified as an antitumor
antibiotic. Antitumor antibiotics are made from natural products produced by
species of the soil fungus Streptomyces. These drugs act during multiple phases
of the cell cycle and are considered cell-cycle specific.

MEDICINE USES :

Doxorubicin is used for the various treatments like Acute
lymphoblastic leukemia (ALL), Acute myeloblastic leukemia (AML), Bone sarcoma,
Breast cancer, Endometrial cancer, Gastric cancer, Head and neck cancer,
Hodgkin lymphoma, Non-Hodgkin lymphoma, Liver cancer, Kidney cancer, Multiple
myeloma, Neuroblastoma, Ovarian cancer, Small Cell Lung cancer, Soft tissue
sarcoma, Thyomas, Thyroid cancer, Transitional cell bladder cancer, Uterine
sarcoma, Wilms’ tumor and Waldenström macroglobulinemia

DOXORUBICIN COMMON SIDE EFFECTS:

Missed menstrual periods; darkening of your skin or nails;
temporary hair loss; feeling weak or tired; mild nausea, diarrhea; or eye
redness, puffy eyelids.

Call your doctor at once if you have:

 feeling short of breath
(even with mild exertion), swelling, rapid weight gain; fever, chills, body
aches, flu symptoms, sores in your mouth and throat; pale skin, easy bruising,
unusual bleeding, feeling like you might pass out;
chest pain, sudden cough, cough with foamy mucus, rapid
breathing, coughing up blood; lower back pain, blood in your urine, little or
no urinating;
Doxorubicin may cause your urine to turn a reddish-orange
color. This side effect by itself is usually not harmful. However, call your
doctor if you also have upper stomach pain, clay-colored stools, or jaundice
(yellowing of your skin or the whites of your eyes).

Call your doctor for medical advice about side effects.

ADRIAMYCIN DOXORUBICIN INJECTION PRECAUTIONS :

·        
Before
using Adriamycin, tell your doctor or pharmacist if you are allergic to it; or
to lincomycin; or if you have any other allergies. This product may contain
inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.

·        
Before
using this medication, tell your doctor or pharmacist your medical history,
especially of: a current infection, low blood cell counts (e.g., anemia,
neutropenia, thrombocytopenia), gout, heart problems (e.g., recent heart
attack, heart failure, irregular heartbeat), a history of receiving any
anthracycline-type drug (e.g., Adriamycin, idarubicin, daunorubicin,
mitoxantrone), kidney problems, liver disease, severe mouth sores (stomatitis),
radiation treatment (especially to the chest area).

·        
This
medication may lower sperm count or may cause abnormal sperm to form, possibly
causing infertility or birth defects. Consult your doctor for more details.

·        
This medication
can affect menstruation in females and cause premature menopause. Consult your
doctor or pharmacist for details.

·        
This
medication is not recommended for use during pregnancy. It may harm an unborn
baby. It is recommended that men and women use effective forms of birth control
(e.g., condoms and birth control pills) while being treated with this
medication and for 6 months after stopping the medication. Consult your doctor
for more details and to discuss reliable forms of birth control.

STORAGE REQUIREMENTS:

Refrigerate unopened vials of Doxil at 2°– 8°C (36°– 46°F).
Do not freeze.

DRUG INTERACTIONS:

Medicines that may harm the liver (eg, acetaminophen,
mercaptopurine, methotrexate, ketoconazole, isoniazid, certain medicines for
HIV infection) because the risk of Doxorubicin’s side effects may be increased.
Ask your doctor if you are unsure if any of your medicines might harm the liver

This document does not contain all possible interactions.
Keep a list of all your medications with you, and share the list with your
doctor and pharmacist.